Publications

Selected Publications

The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis. Kosack L*, Gawish R*, Lercher A, Vilagos B, Hladik A, Lakovits K, Bhattacharya A, Schliehe C, Mesteri I, Knapp S#, Bergthaler A#. Scientific Reports 2017 Sept 12 (*, # these authors contributed equally)

Bhattacharya A*, Hegazy AN*, Deigendesch N, Kosack L, Cupric J, Kandasamy RK, Hildebrandt A, Merkler D, Kühl AA, Vilagos B, Schliehe C, Panse I, Khamina K, Baazim H, Arnold I, Flatz L, Xu HC, Lang PA, Aderem A, Takaoka A, Superti-Furga G, Colinge J, Ludewig B, Löhning M#, Bergthaler A#. Superoxide dismutase 1 protects hepatocytes from type I interferon-driven oxidative damage. Immunity (2015) Nov 17;43(5):974-86. (*, # these authors contributed equally)pdf_icon

Johnson S*, Bergthaler A*, Graw F*, Flatz L, Bonilla W, Siegrist CA, Lambert PH, Regoes R, Pinschewer DD. Protective efficacy of individual CD8+ T cell specificities in chronic viral infection. Journal of Immunology (2015) Feb 15;194(4):1755-62. (* these authors contributed equally)

Schliehe C, Flynn EK, Vilagos B, Richson U, Swaminathan S, Bosnjak B, Bauer L, Kandasamy RK, Griesshammer IM, Kosack L, Schmitz F, Litvak V, Sissons J, Lercher A, Bhattacharya A, Khamina K, Trivett AL, Tessarollo L, Mesteri I, Hladik A, Merkler D, Kubicek S, Knapp S, Epstein MM, Symer DE, Aderem A, Bergthaler A. The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection. Nature Immunology. 2014 Jan;16(1):67-74. 2015

Bergthaler A*, Flatz L*, Hegazy AN, Johnson S, Horvath E, Löhning M and Pinschewer DD. 2010. The viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression. Proceedings of the National Academy of Sciences USA 2010 Dec 14;107(50):21641-6. (* these authors contributed equally) pdf_icon

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All Publications

2017

The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis. Kosack L*, Gawish R*, Lercher A, Vilagos B, Hladik A, Lakovits K, Bhattacharya A, Schliehe C, Mesteri I, Knapp S#, Bergthaler A#. Scientific Reports 2017 Sept 12 (*, # these authors contributed equally)

Circulating and Tissue-resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function is Altered During Inflammation. Hegazy AN, West NR, Stubbington MJT, Wendt E, Suijker KIM, Datsi A, This S, Danne C, Campion S, Duncan SH, Owens BMJ, Uhlig HH, McMichael A; Oxford IBD Cohort Investigators, Bergthaler A, Teichmann SA, Keshav S, Powrie F. Gastroenterology. 2017 Aug 3. pii: S0016-5085(17)35979-6.

Tisantoulas D, Kiss M, Bartolini-Gritt B, Bergthaler A, Mallat Z, Jumaa H, Binder CJ. Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development. Scientific Reports. 2017 Jun 14;7(1):3540. 2017

Leite FGG, Bergthaler A, Skern T. Vaccinia virus G1 protein: absence of autocatalytic self-processing. Archives of Virology. 2017 May 18. 2017

Bergthaler A, Menche J. The immune system as a social network. Nature Immunology. 2017 Apr 18;18(5):481-482. 2017

2016

Newman DM, Sakaguchi S, Lun A, Preston S, Pellegrini M, Khamina K, Bergthaler A, Nutt SL, Smyth GK, Voss AK, Thomas T, Ellmeier W, Belz GT, Allan RS. Acetylation of the Cd8 Locus by KAT6A Determines Memory T Cell Diversity. In press in Cell Reports.  2016 Sep 20;16(12):3311-3321. 2016 pdf_icon

Rothchild AC, Sissons JR, Shafiani S, Plaisier C, Min D, Mai D, Gilchrist M, Peschon J, Larson RP, Bergthaler A, Baliga NS, Urdahl KB, Aderem A. A miR-155-regulated molecular network orchestrates cell fate in the innate and adaptive immune response to Mycobacterium tuberculosis. In press in Proceedings of the National Academy of Sciences USA. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6172-E6181. 2016 pdf_icon

2015

Bhattacharya A*, Hegazy AN*, Deigendesch N, Kosack L, Cupric J, Kandasamy RK, Hildebrandt A, Merkler D, Kühl AA, Vilagos B, Schliehe C, Panse I, Khamina K, Baazim H, Arnold I, Flatz L, Xu HC, Lang PA, Aderem A, Takaoka A, Superti-Furga G, Colinge J, Ludewig B, Löhning M#, Bergthaler A#. Superoxide dismutase 1 protects hepatocytes from type I interferon-driven oxidative damage. Immunity (2015) Nov 17;43(5):974-86. (*, # these authors contributed equally)pdf_icon

Sommerstein R, Flatz L, Remy MM, Malinge P, Magistrelli G, Fischer N, Sahin M,  Bergthaler A, Igonet S, Meulen JT, Rigo D, Meda P, Rabah N, Coutard B, Bowden TA, Lambert PH, Siegrist CA, Pinschewer DD. Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection. PLoS Pathogens (2015) Nov 20;11(11):e1005276 pdf_icon

Johnson S*, Bergthaler A*, Graw F*, Flatz L, Bonilla W, Siegrist CA, Lambert PH, Regoes R, Pinschewer DD. Protective efficacy of individual CD8+ T cell specificities in chronic viral infection. Journal of Immunology (2015) Feb 15;194(4):1755-62. (* these authors contributed equally)

Sakaguchi S, Hombauer M, Hassan H, Tanaka H, Yasmin N, Naoe Y, Bilic I, Moser MA, Hainberger D, Mayer H, Seiser C, Bergthaler A, Taniuchi I, Ellmeier W. A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8aa+ dendritic cells. Journal of Leucocyte Biology 2015 Apr;97(4):635-44. 2015

2014

Schliehe C, Flynn EK, Vilagos B, Richson U, Swaminathan S, Bosnjak B, Bauer L, Kandasamy RK, Griesshammer IM, Kosack L, Schmitz F, Litvak V, Sissons J, Lercher A, Bhattacharya A, Khamina K, Trivett AL, Tessarollo L, Mesteri I, Hladik A, Merkler D, Kubicek S, Knapp S, Epstein MM, Symer DE, Aderem A, Bergthaler A. The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection. Nature Immunology. Jan;16(1):67-74. 2014.

McIlwain DR, Grusdat M, Pozdeev VI, Xu HC, Shinde P, Reardon C, Hao Z, Beyer M, Bergthaler A, Häussinger D, Nolan GP, Lang KS, Lang PA. T-cell STAT3 is required for the maintenance of humoral immunity to LCMV. European Journal of Immunology. 2014 Nov 13.

Sommerstein R, Ramos da Palma J, Olschläger S, Bergthaler A, Barba L, Lee BP, Pasquato A, Flatz L. Evolution of recombinant lymphocytic choriomeningitis virus/Lassa virus in vivo highlights the importance of the GPC cytosolic tail in viral fitness. Journal of Virology. 2014 Aug;88(15):8340-8. Epub 2014 May 14.

2013

Belnoue E, Fontannaz P, Rochat AF, Tougne C, Bergthaler A, Lambert PH, Pinschewer DD, Siegrist CA. Functional limitations of plasmacytoid dendritic cells limit type I interferon, T cell responses and virus control in early life. PLoS One 2013 Dec 23;8(12):e85302. pdf_icon

Kreutzfeldt M*, Bergthaler A*, Fernandez M, Brück W, Steinback K, Vorm M, Coras R, Blümcke I, Bonilla WV, Fleige A, Forman R, Müller W, Becher B, Misgeld T, Kerschensteiner M, Pinschewer DD*, and D. Merkler*. 2013. Neuroprotective intervention by interferon-g blockade prevents CD8+ T cell-mediated dendrite and synapse loss. Journal of Experimental Medicine 2013 Sep 2. (* these authors contributed equally)

2012

Litvak V, Ratushny AV, Lampano AE, Schmitz F, Huang AC, Raman A, Rust AG, Bergthaler A, Aitchison JD and A. Aderem. 2012. A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses. Nature 2012 Sep 16.

2010

Bergthaler A*, Flatz L*, Hegazy AN, Johnson S, Horvath E, Löhning M and Pinschewer DD. 2010. The viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression. Proceedings of the National Academy of Sciences USA 2010 Nov 22. (* these authors contributed equally) pdf_icon

Pinschewer DD, Flatz L, Horvath E, Fernandez M, Steinborn R, Suter M, Lutz H and  Bergthaler A#. 2010. Innate and adaptive immune control of genetically engineered live-attenuated arenavirus vaccine prototypes. International Immunology. 2010 Sep;22(9):749-56. Epub 2010 Jun 28. pdf_icon

Flatz L*, Rieger T*, Merkler D*, Bergthaler A, Regen T, Schedensack M, Bestmann L,  Verschoor A, Kreutzfeldt M, Brück W, Hanisch UK, Günther S, and Pinschewer DD. 2010. T Cell-Dependence of Lassa Fever Pathogenesis. PLoS Pathogens 2010 6(3): e1000836. (* these authors contributed equally) pdf_icon

Pinschewer DD, Schedensack M, Bergthaler A, Horvath E, Brück W, Löhning M and  Merkler D. T cells can mediate viral clearance from ependyma but not parenchyma in a major histocompatibility class I- and perforin-independent fashion. Brain 2010 April. pdf_icon

Flatz L, Hegazy AN*, Bergthaler A*, Verschoor A*, Claus A, Fernandez M, Gattinoni L,  Johnson S, Kreppel F, Kochanek S, Broek MD, Radbruch A, Lèvy F, Lambert PH,  Siegrist CA, Restifo NP, Löhning M, Ochsenbein AF, Nabel GJ, and Pinschewer DD. 2010. Development of propagation-deficient arenavirus vaccine vectors for induction of potent CD8+ T cell immunity. Nature Medicine 2010 Febr 14 [Epub ahead of print]. (* these authors contributed equally) (featured as Research Highlight in Nature Biotech and in Nature Reviews Immunology)

Hegazy AN, Peine M, Helmstetter C, Panse I, Fröhlich A, Bergthaler A, Flatz L,  Pinschewer DD, Radbruch A and Löhning M. 2010. Interferon-mediated T-bet induction in T helper 2 cells prevents viral persistence and fatal immunopathology. Immunity 2010 Jan 13 [Epub ahead of print]. (Cover image and featured article, highlighted in Nature Reviews Immunology)

2009

Bergthaler A, Flatz L, Verschoor A, Hegazy AN, Holdener M, Fink K, Eschli B, Merkler D, Horvath E, Fernandez M, Fitsche A, Senn BM, Odermatt B, Siegrist CA, and Pinschewer DD. 2009. Impaired antibody response allows persistence of prototypic T cell-contained virus. PLoS Biology 2009 Apr 7 7(4):e80. (featured as Research Highlight in Nature Reviews Immunology and as Must Read in Faculty of 1000) pdf_icon

2007

Bergthaler A, Merkler D, Horvath E, Bestmann L, and Pinschewer DD. 2007. Contributions of the lymphocytic choriomeningitis virus glycoprotein and polymerase to strain-specific differences in murine liver pathogenicity. Journal of General Virology 88:592-603. pdf_icon

Recher M, Lang KS, Navarini A, Hunziker L, Lang PA, Fink K, Freigang S, Georgiev P, Hangartner L, Zellweger R, Bergthaler A, Hegazy AN, Eschli B, Theocharides A, Jeker LT, Merkler D, Odermatt B, Hersberger M, Hengartner H, and Zinkernagel RM. 2007. Extralymphatic virus sanctuaries as a consequence of potent T-cell activation. Nature Medicine 13:1316-1323.

Lang KS, Navarini AA, Recher M, Lang PA, Heikenwalder M, Stecher B, Bergthaler A,  Odermatt B, Akira S, Honda K, Hengartner H, and Zinkernagel RM. 2007. MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus. European Journal of Immunology 37:2434-2440. pdf_icon

2006

Lang KS, Georgiev P, Recher M, Navarini AA, Bergthaler A, Heikenwalder M, Harris NL, Junt T, Odermatt B, Clavien PA, Pircher H, Akira S, Hengartner H, and Zinkernagel RM. 2006. Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling. Journal of Clinical Investigations 116:2456-2463. (featured as a Must Read in Faculty of 1000) pdf_icon

Navarini AA, Recher M, Lang KS, Georgiev P, Meury S, Bergthaler A, Flatz L, Bille J,  Landmann R, Odermatt B, Hengartner H, and Zinkernagel RM. 2006. Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses. Proceedings of the National Academy of Sciences USA 103:15535-15539. pdf_icon

Flatz L*, Bergthaler A*, de la Torre JC and Pinschewer DD. 2006. Recovery of an arenavirus entirely from RNA polymerase I/II-driven cDNA. Proceedings of the National Academy of Sciences USA 103:4663-4668. (* these authors contributed equally) pdf_icon

Bergthaler A, Gerber NU, Merkler D, Horvath E, de la Torre JC, and Pinschewer DD. 2006. Envelope exchange for the generation of live-attenuated arenavirus vaccines. PLoS Pathogens 2:e51. pdf_icon

Complete list of publications

m_papers