Research Interests

Our group`s focus lies on pathogen-host interactions and viral diseases. We want to contribute to a better mechanistic understanding of viral pathogenesis and the multilayered antiviral immune system. How do viruses make us sick? How is our body`s immune system counteracting a viral infection? Under which conditions does the immune response unintentionally cause immunopathology to the host? Can we identify novel targets to intervene therapeutically in viral diseases? And what is the contribution of metabolism to all of that?

We employ well-defined mouse infections models and an interdisciplinary integrative approach to probe the complex and interdependent dynamics of the virus and the host`s immune system. In particular, we are interested in the following topics:

  • Antiviral T and B cell responses
  • Chronic viral infections
  • Immunopathology
  • Immunosuppression
  • Inflammation
  • Influenza virus
  • Innate immunity
  • Lymphocytic choriomeningitis virus
  • Mass spectrometry
  • Metabolism
  • Molecular virology
  • Mouse disease models
  • Next-generation sequencing
  • Reverse genetics of RNA viruses
  • Superinfection
  • Systems biology
  • Vaccines
  • Viral immune evasion
  • Viral pathogenesis